Lewis B. Williams Jr. (September 13, 1833 – July 3, 1863) was a Confederate Colonel during the American Civil War.

Born in Richmond, Virginia, he was the son of Lewis B. Williams Sr, a Virginian legislator who opposed secession.

General James Kemper's Brigade of Pickett's Division in the Army of Northern Virginia.

Williams led the 1st Virginia on the third day of the Battle of Gettysburg against the Union position on Cemetery Hill in what is called "Pickett's Charge".

Colonel Franklin G. Skinner, continued on toward the Union lines, suffering 80% casualties, before being forced to retreat.