Mayo then attended Wesleyan University from 1850 to 1852.
Mayo was involved in the real estate business, practiced medicine, and was a druggist in Sauk Rapids.
Mayo served as probate judge, school superintendent, district court clerk, coroner, and treasurer for Benton County, Minnesota.
Mayo served in the Minnesota Senate in 1876 and 1877 and was a Democrat.
[1] Mayo died in Sauk Rapids, Minnesota.