Its 19th-century downtown, centered around Market Street, is listed on the National Register of Historic Places.

A settler of the area (since as early as 1763–1769), Derr purchased several tracts of land from the William Penn family and other neighboring landowners, the largest of which was known as "The Prescott".

Having been on the land for such a long time, Derr had befriended the local Native Americans of the area.

His relationship with these indigenous peoples was so well founded that, even as many of the other local settlers' homesteads were routinely sacked by Native Americans, Derr's lands remained free from attacks.

Subsequently, in 1784, he worked with Samuel Weiser to lay out his combined land tracts, and create Derrstown.

The premise is further supported by the notion that the German word for street is Strasse (Straße, abbreviated St).

[citation needed] Over the centuries, Lewisburg has been a center of commerce in Union County.

Prior to, and during, the Civil War, many abolitionists lived in the area, and several locations within the town of Lewisburg served as stopping points on the famous Underground Railroad.

[8] According to the United States Census Bureau, the borough has a total area of 1.0 square mile (2.6 km2), all land.

Officer Hufnagle died saving lives during the Agnes Flood on June 21, 1972.

Opened in 2012, the community garden provides educational opportunities for students and area residents, rents garden plots, and grows and donates 3,800 pounds of organic produce to local food access programs.