During Pontiac's Rebellion in 1763, Native Americans completely destroyed two of the early European settlements in Greenbrier County, killing the men and carrying off the women and children.

The Native Americans were primarily Shawnees, and (according to undocumented tradition) were led by the famous leader Hokoleskwa, or Cornstalk.

In 1774, Governor Dunmore of Virginia instructed then-Colonel Andrew Lewis to gather "willing and able men" to go to the great Kanawha River and stand against the Native American forces that were attacking the Greenbrier Valley.

Among Lewisburg's first trustees was Col. John Stuart (1749-1823), a Revolutionary War commander who surveyed and settled the area and is known locally as the “Father of Greenbrier County”.

[8] To accommodate Virginians west of the mountains, several Virginia courts sat in Lewisburg, where Patrick Henry once successfully defended a client accused of murder.

The town and the surrounding farms prospered and a number of spas and resort hotels were established at some of the outlying mineral springs.

Several of the present buildings in town were used as hospitals and barracks by both sides in this conflict, and bullet marks can still be seen in some today.

This Girl Scout camp was integrated in the 1950s thanks to the efforts of Charleston civil rights activist Elizabeth Harden Gilmore.

Today, the museum's permanent displays and temporary exhibits feature items from across the Greenbrier Valley, including, but not limit to; the training saddle of General Robert E. Lee's horse Traveller, an 18th-century covered wagon, Civil War artifacts, furniture made by local craftsman David Surbaugh, as well as original items from the North family.

The Greenbrier Historical Society archives and museum hold artifacts from before the revolutionary war through today.

The Greenbrier Historical Society and North House Museum also offers educational program, a research archive, group tour rates, and membership opportunities.

The Lewisburg post office holds a mural, Old Time Camp Meeting, painted by American artist Robert F. Gates as part of President Franklin Roosevelt's New Deal.

[23][24] The Lost World Caverns are nearby, and feature self-guided tours and numerous rock formations.

Lewisburg is the site of West Virginia's largest Martin Luther King Jr. Day celebration.

The event includes a march through downtown Lewisburg, a community lunch, and a program commemorating the memory and legacy of Dr. King.

[1][25][2] The Greenbrier Classic Concert series are held in nearby Fairlea at the State Fair Grounds every July.

Artists who have performed include West Virginia native Brad Paisley, Carrie Underwood, Keith Urban, Reba McEntire.

Miranda Lambert, Rod Stewart, Lionel Richie, Victoria Justice, Jon Bon Jovi, Kenny Chesney, Aerosmith, Maroon 5 and Jimmy Buffett.

Greenbrier Valley Airport supports a vibrant general aviation community, and also has direct daily flights on Contour Airlines to Charlotte, NC.