[2] In the 11th century the manor of Luvechenora was held by Edith of Wessex, who in 1045 became queen consort of Edward the Confessor.

The manor then passed to a Danish thegn of King Edward called Tovi, who bequeathed it to Abingdon Abbey.

[2] All Souls College, Oxford had become a major landowner in the parish before the end of the 17th century[2] and has remained so until modern times.

[8] The chancel arch, north chapel, two lancet windows in the nave, the font and some other features survive from this time.

[2] In 1863 the nave was restored, re-roofed and had two more windows inserted under the direction of the Gothic Revival architect Arthur Blomfield.

Lewknor Uphill consisted of three detached parts in the Chiltern Hills: Ackhampstead, Cadmore End and Studdridge.

It ran right past the village but the nearest station it provided was 1 mile (1.6 km) away at Aston Rowant.

[15] Aston Rowant remained open for freight only until 1961, when British Railways withdrew this service and removed the track south of Chinnor cement works.

South of the village the motorway climbs the Chiltern escarpment in a cutting up to 150 feet (46 m) deep[3] with steep chalk faces.

51 Squadron RAF, was returning from the Nuremberg Raid when it crashed in Cowleaze Wood, in the Chiltern Hills about 1+1⁄2 miles (2.4 km) southeast of Lewknor village, killing all seven of its crew.

[19] In 1965 the Chilterns including the escarpment and hills in the parish were declared an Area of Outstanding Natural Beauty.

[20] On the escarpment on either side of the motorway is Aston Rowant National Nature Reserve, which despite its name is partly in Lewknor parish.

The reserve has beech woodlands, chalk grassland supporting diverse rare plants and butterflies, and is one of the best places in England to see red kites.