22.50% of all households were made up of individuals, and 6.90% had someone living alone who was 65 years of age or older.

Lexington County was one of the first areas of South Carolina to support the Republican Party.

The last official Democratic candidate to carry the county at a presidential level was Franklin D. Roosevelt in 1944, and the official Democratic candidate last won 40 percent of the county's vote in 1952.

[21] The county's Republican bent is not limited to national politics; its voters frequently reject Democrats at the state level as well.

In 1986, it was the only county in the state to support Hollings' Republican opponent, future Governor Henry McMaster.

[24] It was one of the first areas where Republicans broke the long Democratic monopoly on state and local offices; today, longtime state senator Nikki Setzler is the only elected Democrat above the county level.

On November 4, 2014, Lexington County residents voted against a proposed sales tax increase.

The money generated from this tax would have mostly been used to improve traffic conditions upon roadways.

[25] That same day, residents voted to repeal a ban on alcohol sales on Sundays within the county.

[26] In 2015, long-time county sheriff James Metts pled guilty to charges of conspiring to harbor and conceal illegal aliens.

[32] The Saxe Gotha Industrial Park near Cayce houses multiple distribution sites for major national companies, including Amazon, Chick-fil-A, The Home Depot and Nephron Pharmaceuticals.

Other manufacturers include Shaw Industries, Southeastern Freight Lines, and Flex, at which president Biden spoke in July 2023.

Additionally, the airport is also the regional hub for UPS Airlines, transporting 136.7 million pounds of freight/mail in 2018.

Public transportation in Lexington County is provided by the COMET, or officially the Central Midlands Regional Transit Authority (CMRTA).

In Lexington County, the bus system runs in the areas of West Columbia, Cayce, Irmo, Springdale, Seven Oaks, and Harbison.

Additionally, COMET offers Dial-a-ride transit (DART), which provides personalized service passengers with disabilities.