In 1879, a surgeon general and the Government of Bombay recommended to the Commissioner in Sind to start a medical school.

Sindh Medical School was subsequently started by Dr. Homestead and inaugurated by Henry Napier Bruce Erskine, the Commissioner in Sind province at the time, in 1881.

The college with its journey and natural growth for more than 62 years made tremendous contributions in both medical education and health care in the province and the country.

After an ordinance was passed by Government of Sindh in 2001, it was upgraded to the status of the first public-sector medical university of the country.

The university offers degrees in the following departments: Around 350 medical students graduate every year and practice medicine in their respective districts and/or pursue postgraduate studies.

It soon became recognized for its training of FCPS and MCPS in all disciplines of medicine, surgery, dentistry and allied sciences.

[27] First ever endoscopic discectomy surgery in any public sector hospital of Sindh was also performed at the university's neurosurgery department.

Liaquat Medical Research Journal (LMRJ) [ISSN (Print): 2664-5734] is a print and online (double blind, peer-reviewed) journal devoted to publishing innovative research and scholastic / academic content from all fields of medical and health sciences, concentrating on recent advances in clinical, diagnostic and preventive domains.

The Medical Research Center (MRC) promotes the health of people in Pakistan and around the world by sponsoring good science and training scientists.