Libinia spinosa is a majoid crab found in mud and sand bottoms of the Southwestern Atlantic and Pacific oceans.

It is a generalist feeder on organisms such as algae, sponges, cnidarians, mollusks, polychaetes, crustaceans, and small fish.

[3] Libinia spinosa is commonly found at both mud and sand bottoms in the Southwestern Atlantic and Pacific oceans.

[2][4] In the Pacific Ocean, it is found off the coasts of the United States, Baja California, Galápagos Islands, Hawaii, Peru, and Chile.

[5] Libinia spinosa engage in precopulatory courting using both olfactory and tactile cues, indirect sperm transfer is common.

[9]Libinia spinosa does not have commercial value but is unintentionally caught in prawn trawls, an activity which has led to a decline in its population.

[5] Libinia spinosa has been shown to engage in a symbiotic relationship with the medusa Lychnorhiza lucerna, mainly during its juvenile stages.

[5] There is no clear benefit to Lychnorhiza lucerna hosting Libinia spinosa so their symbiotic relationship is likely a form of commensalism.