Although Twain was actually 21 when he began his training, he uses artistic license to make himself seem somewhat younger, referring to himself as a "fledgling" and a "boy" who "ran away from home" to seek his fortune on the river, and playing up his own callowness and naïveté.

In the second half, Twain narrates his trip many years later on a steamboat from St. Louis to New Orleans, shortly followed by a steamboat journey from New Orleans to St Paul (with a stop at his boyhood home town of Hannibal, MO).

He describes the competition from railroads, and the new, large cities, and adds his observations on greed, gullibility, tragedy, and bad architecture.

[4] In 1980, the book was adapted as a TV movie for American public television, with David Knell performing as Samuel Clemens (Mark Twain's real name) and Robert Lansing as Horace Bixby, the steamboat pilot who mentored him.

In 2013, Life on the Mississippi, a musical play by Philip Hall, was performed at the Workshop Theater Company in New York.