Lindbergh Boulevard is home to Missouri's only traffic tunnel underneath a runway at Lambert–St.

Lindbergh Boulevard was initially a bypass of St. Louis, designated in about 1930 as Route 77 from Mehlville to the Chain of Rocks Bridge.

That portion became part of US 50 when it was moved onto the bridge, and US 67 eventually replaced Route 140.

It loses US 50 to I-44, at which point US 61 and US 67 continue north as Kirkwood Road, named after the suburb they pass through.

From Florissant northward, US 67 continues as Highway 67 North, discontinuing the Lindbergh name.