[2] The link domain is found in some extracellular proteins in vertebrates such as the hyalectans.

[3] It appears to be involved in extracellular matrix assembly and stability, cell adhesion, and migration.

[3][4] The structure has been shown to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core similar to that of C-type lectin.

[5] This domain contains four conserved cysteines involved in two disulphide bonds.

The link domain has also been termed HABM (hyaluronic acid binding module)[4] and PTR (proteoglycan tandem repeat).