In molecular biology, linker DNA is double-stranded DNA (38-53 base pairs long) in between two nucleosome cores that, in association with histone H1, holds the cores together.
Linker DNA is seen as the string in the "beads and string model", which is made by using an ionic solution on the chromatin.
[1] The linkers are short double stranded DNA segments which are formed of oligonucleotides.
These contain target sites for the action of one or more restriction enzymes.
These are then treated with restriction endonuclease enzyme to produce cohesive ends of DNA fragments.