He has been a full Professor of Thermotronics in the Department of Mechanical and Process Engineering at the institute for dynamic systems and control (IDSC) since 1999.

In his research, Lino Guzzella works on modelling and model-assisted optimisation and control of energy technology and mechatronic systems.

Professor Guzzella's team designed the PAC-Car II, a hydrogen fuel cell vehicle that won the Energy Globe Award in November 2005.

His ultimate goal would be to create zero-emission cars, stating that the real challenge lies in reducing costs of hydrogen and developing its production from renewable sources.

In 2006, Prof. Guzzella appeared as a guest panellist, along with BT futurist Ian Pearson, space tourist Anousheh Ansari and renowned American astronaut Buzz Aldrin on the CNN Future Summit: World in Motion programme, presented by Richard Quest in Singapore.