Born in Rome, Landolfi attended various art schools including the Accademia where he studied painting, sculpture, decorating and scenery.
[1] He debuted as a cartoonist in 1947 with the character of "Joe", published by Corriere dei Piccoli.
[1] In 1951 he created his most popular character, Procopio, realized for the magazine Il Vittorioso until 1968.
[1] In 1968, he changed his usual graphic style for a critically appreciated grotesque-realistic version of Don Quixote published by Vitt.
[1][2] In 1969 he started a collaboration with the children magazine Il Giornalino, for which Landolfi, in addition to having made several comic adaptations from literary such as Gulliver's Travels and Father Brown, co-created with writer Claudio Nizzi the popular "Piccolo Dente", leading character of a long lasting eponym comic strip.