[2] Each show started with a rundown of the headlines that featured in that edition of Liquid News after the main titles and the host introducing themselves.

The show would divide itself into sections of discussion which usually fell into the categories of Music, Film, Television and sometimes Sport which featured a main story of a pre-recorded or insert live from the regular roster of Liquid News reporters.

The 7 O'Clock News was later axed in December 2005, while 60 Seconds departed screens alongside the original incarnation of BBC Three as a linear channel in February 2016.

Following his death on 21 April 2002, the show continued with a variety of presenters, beginning with Dale Winton and also including Colin Paterson, Claudia Winkleman, Julia Morris, Iain Lee, Jasmine Lowson, Paddy O'Connell, Lorraine Kelly, Phill Jupitus, Julian Clary, Jonathan Ross, Jo Whiley, Joe Mace and Amanda Byram.

The lineup of reporting staff included Colin Paterson, Stephanie West, Vanessa Langford, Tamzin Sylvester and Ruth Liptrot.