[1] Born in Louisville, Kentucky, Harrison learned to play basketball from a young age.

In the 1999 WNBA draft, she was selected by the Phoenix Mercury in the third round (34th pick overall).

In the WNBA, Lisa was once ranked eighth in free throw shooting accuracy at 86.4% in 2001.

Harrison was inducted into the Kentucky High School Athletics Hall of Fame on September 10, 2001.

On September 12, 2006, Harrison was named an outreach coordinator for the athletic department at the University of Louisville.