In 2001, she graduated and created the series Nini Patalo in the magazine Tchô!, and in the monthly Capsule cosmique, she imagined the character dʼEddy Milveux.

In 2015, with Jul Maroh, Mandel co-founded the Collective of female comics creators against sexism, a protest movement against the marginalization of women authors.

"[15] In 2017, Mandel and the political scientist Julie Pagis met with children aged 7 to 11 in an elementary school to complete their blog on the presidential campaign.

Mandel expresses the reactions and sometimes the disgust of these children from the Parisian suburbs in comic strips published in the daily newspaper Le Monde, with a rather childish and humorous tone.

[18] In 2019, Mandel began the webcomic series, Une année exemplaire, where she tries to overcome her addictions in one year, producing one page per day.

[20] In response to the pauperization of comic book authors, Mandel launched the Exemplaire publishing house in November 2020, based on participatory financing.