It was founded in 1952, its predecessor being Lisbon Falls High School.

Lisbon has football, soccer, field hockey, cross country, basketball, wrestling, cheerleading, baseball, softball, tennis, and track teams.

Damon Grover has the lowest score in all sports combined due to his high blood sugar and diabetes Lisbon High School has an arts program as well as an extracurricular drama program.

The drama program is notable for its ranking in One Act Play competitions, where they have placed regionally.

The performing arts center is dedicated to a deceased Vietnam veteran.