Lisha Kill lies on New York Route 5 (Central Avenue) in the western section of the town.

The stream is also referred to as Lisha's Kill and received its name from a local legend about a Native American woman who is buried along its banks.

[5] Several Lansings in the late 19th century were deacons, elders, and officers of the (Dutch) Reformed Church of Lisha's Kill.

[7] The Albany and Schenectady Turnpike, built in 1799, connecting those two cities ran through the middle of Lisha Kill and had a toll-gate here.

[7][8] Lisha Kill is centered along Central Avenue (NY Route 5) in the western part of Colonie, between the cities of Albany and Schenectady.