The series focuses on a squad of youthful-looking undercover police officers investigating crimes in high schools, colleges, and other teenage venues.
Hanson goes undercover to investigate a series of burglaries at a local high school and learns that both the burglar and a student are obsessed with one of the teachers who works there, Miss Chadwick.
The entire Jump Street gang investigates the rape and murder of a 16-year-old girl by going undercover in a private school, where much of the student body are kids from affluent families.
While still mourning the loss of Captain Jenko in a drunk driving crash, Hanson and Hoffs are assigned to get close to a high school principal after he receives death threats from a gang leader that he stood up to.
While busting drug dealers, Hanson and Penhall (in their "McQuaid brothers" cover) discover a girl who is being sexually abused by her father, a high-ranking police officer.
The son of a loan shark continues the family tradition, starting up his own cash-loan operation in a local high school and physically assaulting students and teachers who do not repay their debt on time.
Hoffs befriends a promising young high school baseball player from New York City who is in the federal witness protection program.
Officers Ioki and Hoffs go undercover in a teen modeling agency that is suspected to be a front for a pornography ring that exploits minors.
Meanwhile, Captain Fuller comes across a down-and-out woman he previously arrested and sets his sights on the modeling academy's owner, in an effort to find those responsible for coercing the girls into making these films and bring them to justice.
A 16-year-old crack dealer is mysteriously murdered and the Jump Street squad goes undercover in the seedy world of narcotics and prostitution.
The Jump Street squad puts a sting on a bar serving alcohol to underage kids and ironically discovers that their own captain has been arrested for drunk driving.
Tyrell "Waxer" Thompson, the drug dealer busted by Officer Hanson in his first Jump Street case, escapes state custody while being transported to an adult prison.
After discovering that Hanson is working undercover to protect a Hollywood heartthrob in town filming a movie, Waxer looks to settle the score.
To pacify their dateless state on Valentine's Day, the Jump Street squad plays poker and reminisces about their worst dates, while Hanson recollects on his prom night when his father was killed.
Officers Hanson and Penhall pose once again as the battling McQuaid brothers to infiltrate a gang of students being bussed from the wrong side of the tracks.
While Hanson and Booker try to catch a drug dealer, their investigation is impeded by a gang of young vigilantes known as The Rangers committed to help clean the streets of crime and violence.
Penhall almost wrings a confession from an alleged child molester, only to learn that his accuser—his soon-to-be ex-wife— recanted and admitted to lying to the police in order to retain sole custody of the couple's daughter.
Officers Penhall and Booker join an all-state football team to investigate possible criminal negligence on the part of the coach when his star linebacker is paralyzed for life.
When Russell Buckins pens a dangerously revealing magazine article about the Jump Street program, Officer Hanson is suspended and goes gunning for his old friend.
Officers Penhall, Hoffs, and Ioki investigate a priest in a Catholic university suspected of selling Salvadorean babies to finance an underground sanctuary movement.
Hanson is invited to witness the execution of Ronnie Seebook, who is on death row for murdering a convenience store clerk, and asks the condemned inmate to make a film to scare off children from becoming criminals.
Former DEA agent Kati Rocky has joined the Jump Street program, and partners with Garrett to investigate a recurrence of drug dealing at a school recently busted by the other officers.