He is known for his role as Officer Doug Penhall in the Fox TV series 21 Jump Street and for directing and writing episodes of science fiction television shows, particularly in the Stargate franchise.

He appeared as Officer Doug Penhall in the 1987 Fox series 21 Jump Street[2] with other promising actors including Johnny Depp.

[3] DeLuise has made guest appearances on the television shows The Facts of Life, 21 Jump Street spin-off Booker, Friends, Supernatural, Highlander: The Series, Gene Roddenberry's Andromeda, and Stargate SG-1.

Peter also made a cameo in the episode as the "Urgo" character transformed to be a young man in a United States Air Force uniform.

[5] Depp, DeLuise and Holly Robinson reprised their roles as Tom Hanson, Doug Penhall and Judy Hoffs, respectively.