Initially debuting on February 26, 1995, as a seven-minute World Premiere Toons pilot, it was expanded into a full series after gaining network approval.
However, Tartakovsky directed a television movie titled Dexter's Laboratory: Ego Trip which aired on Cartoon Network on December 10, 1999.
[3] The third-season episode "Poppa Wheely/A Mom Cartoon/The Mock Side of the Moon" is the first to feature Christine Cavanaugh's replacement Candi Milo as the voice of Dexter.
A previously unaired episode called "Rude Removal" was originally shown only at certain comic conventions that Tartakovsky attended beginning in 1998.
[4] An episode segment from the second season was produced yet never aired on television, but was ultimately released to the public in January 2013 on the official YouTube page of Adult Swim.