This is an alphabetical list of baseball players from Panama who played in Major League Baseball between 1955 and 2024.
The first Panamanian ever to appear in the Majors was Humberto Robinson.
Major League Baseball - In order of MLB debut (oldest - newest) Minor League Baseball ^These three form the SSS islands that with the ABC islands comprise the Dutch Caribbean, of which *the BES islands are not direct Kingdom constituents but subsumed with the country of the Netherlands.
†Physiographically, these continental islands are not part of the volcanic Windward Islands arc, although sometimes grouped with them culturally and politically.
ǂDisputed territories administered by Guyana.