Tired of being unappreciated, Squirt switches places with a rich lookalike named Cuddlesworth (Ted Biaselli), who desires to become a Pound Puppy.
While Cuddlesworth realizes that being a Pound Puppy isn't as fun as he thought, his servant (Charles Shaughnessy) takes Squirt to a mansion, where he meets a cat named Madame Pickypuss (Tress MacNeille).
Puppy: Rebound Tired of being left behind on missions because of her shape, Strudel gets her chance to shine when she is tasked with guiding a circus dog named Chuckles (Tom Kenny) back to his home.
Reaching the big top, she becomes part of a circus act that must succeed to prevent a greedy ringmaster (Kevin Michael Richardson) from canceling it for good.
Milton Feltwaddle (Jim Parsons) brings a super-intelligent robot dog named Toyoshiko (Ashley Johnson) to the pound, who understands Strudel.
After Zoltron (French Stewart) gets separated from his family during an outing, he needs help from the Pound Puppies to be reunited with his people, and the pups soon make the discovery that their new companion may or may not be from planet Earth.
Cookie has been feeling ignored due to her family's busy schedules and becomes close to a puppy she names Cupcake (Cree Summer).
Lucky is adopted against his will by an eccentric social outcast named Dot (Grey DeLisle), but his new owner's over-affectionate ways make him uncomfortable.
In addition, Rebound, Cupcake and Patches are featured in the opening theme during the second season giving tags to the puppies going to their new homes.
Meanwhile, the legendary Dash Whippet (Corey Burton) pays the Pound Puppies a visit and expects them to find people for his grand-pups.
Niblet shares the Pound Puppies' secrets with a chatty parrot (Frank Welker), that McLeish is watching for his brother-in-law, the mayor (John Larroquette).
Rebound's song-and-dance skills are on display in a video on the Internet, and the Pound Puppies try to prevent McLeish from exploiting this for fame.
A dog named Miss Petunia (Glenne Headly) gives premature birth to a litter of puppies at Shelter 17, who are mistakenly adopted by a trio of girls.
[5] Dolores (Tara Strong) has to prove to her editor in chief dad (J. K. Simmons) that she is responsible enough to adopt a pup, so she becomes a delivery girl for his newspaper.
The Pound Puppies sneak into a museum to place pup Millie (Jeannie Elias) with Amelia (Ashley Johnson), granddaughter of the curator (Corey Burton).
When McLeish brings Ralph (Fred Stoller) over to Shelter 17, the dog begins scaring off adopters, leaving the Pound Puppies to accuse him of sabotaging their operations.
Ace reveals that he was friends with a puppy a long time ago and he was unable to get over his past and he almost got Spoons hurt because of his overconfidence.
Strudel is challenged by Agent Ping (Lauren Tom) to find the perfect people for an energetic pup named Chief (Justin Shenkarow).
Niblet leads three unique pups on a dangerous journey of self-discovery after listening to motivational speaker Bony Doggins (Jess Harnell).
Lucky's habit of following instinct over rules lands him in front of a Pound Puppy tribunal that could mean the end of Shelter 17 if he is found guilty.