This article lists the prime ministers of Equatorial Guinea, a country in the Gulf of Guinea.

The prime minister of Equatorial Guinea is a member of the Council of Ministers, which is chaired by the president.

Bonifacio Ondó Edu was the first person to hold the preceding office of prime minister of Spanish Guinea, taking effect on 15 December 1963.

The incumbent is Manuel Osa Nsue Nsua, having taken office on 17 August 2024.

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