The main cast include Priyanka Chopra, Jake McLaughlin, Yasmine Al Massri, Johanna Braddy, Tate Ellington, Graham Rogers, Anabelle Acosta as her fellow recruits, and Josh Hopkins and Aunjanue Ellis as their trainers at the FBI academy, Quantico, Virginia.
In the second season, Russell Tovey, Pearl Thusi, and Blair Underwood were added to the main cast following the CIA plot elements.
Alexandra "Alex" Parrish (portrayed by Priyanka Chopra), a former top recruit at Quantico as well as a promising FBI agent was considered a prime suspect in the Grand Central Terminal bombing.
After the negative publicity to the FBI stemming from Liam O'Connor's treachery as well as Simon Asher's death at Quantico, Alex is fired by the organization.
Two months after the presidential election ended, Alex is approached by CIA director Matthew Keyes, who provides an opportunity for her to join and work for the organization.
Months after leaving The Farm, a hostage crisis at the G-20 summit in New York is declared by a terrorist group called the Citizens Liberation Front.
After a national scandal involving the resignation of President Claire Haas along with the disbandment of the task force, Alex resorted to a final strategy.
She released U.S classified intelligence to the public at the Constitutional Convention in Philadelphia, implicating newly inaugurated President Henry Roarke in a deadly conspiracy.
After being issued a Red Notice for her arrest by Interpol, she leaves the country with Ryan Booth on a plane to Thailand in order to evade the authorities.
Years ago, he and Alex's father had graduated from the FBI academy together and one of their first undercover operations in Omaha was a blown sting killing over 200 people.
It was subsequently revealed that he had used hidden cameras and tracking devices to plan the bombings, and had gathered intelligence to blackmail Elias and frame both Alex and Simon.
After the Grand Central Terminal bombing, Ryan is working in the New York Office and is in a relationship with Natalie Vasquez and, along with their friends, helps Alex clear her name.
After his ex-wife, Hannah Wyland, is suspended from active duty after an incident with Senator Haas, Ryan takes over her position under Liam's orders.
Sometime later, Miranda is incarcerated in a federal prison due to orchestrating what appears to be an attempted murder of Alex Parrish at the Constitutional Convention in Philadelphia.
Caleb Haas (portrayed by Graham Rogers; season 1, main; 2, guest) was an FBI trainee who originally flunked out of the Academy as an agent, but was brought back to train as an analyst, and then reinstated as an agent-trainee again.
After the scandal, Shelby was no longer considered an FBI agent because her relationship with Clayton was exposed as part of the process of the congressional testimony for the Command Center bombing.
After graduating summa cum laude from Yale University, he worked as an accountant for his family's company, and later he spent almost two years in the Israel Defense Forces before applying to the FBI.
After the exposure of Liam O'Connor as the perpetrator of the attacks in New York, Simon tried to help his former classmates in defusing another bomb that was implanted by their former instructor at Quantico.
Dayana Mampasi (portrayed by Pearl Thusi; season 2) is a driven, disciplined, type-A lawyer working at her parents' Boston firm who struggles to fit into the world of espionage.
After the 2018 Hostage Crisis ended, Dayana becomes part of the covert joint task force put forth by President Claire Haas and CIA director Matthew Keyes.
Owen Hall (portrayed by Blair Underwood; seasons 2 & 3), a charming, intelligent and inspirational CIA officer who every fledgling operative wishes he or she could learn from.
Following this, Jocelyn was put to work as a Quantico instructor, but is recruited by old friend Owen Hall to assist in the rescue of Agent Shelby Wyatt from "The Widow", and later to be a part of a special black-ops team.
Previously, she worked at the field office in New York before being suspended from active duty due to orchestrating an incident involving former Senator Claire Haas.
At the end of the first season, it was revealed that Claire assisted Liam O'Connor in the execution of his plans so that it would politically benefit her vice presidential campaign.
Drew Perales (portrayed by Lenny Platt) was a retired NFL player and FBI recruit, before leaving the academy due to a medical condition.
Shortly after the 2018 Hostage Crisis ended, it was revealed that he worked with Claire Haas in setting up the Presidential Covert Joint Task Force.
León Velez (portrayed by Aarón Díaz) was a photojournalist and CIA recruit, before leaving Camp Peary as a result of failing a training assignment.
In "Resistance", it was revealed that his former team members from the task force were able to implicate Henry Roarke by exposing his connection to the Russian Federal Security Service.
Maxine Griffin (portrayed by Krysta Rodriguez) is an intelligent, passionate and fiercely driven founder of “the Roster”, a network and visibility platform for professional women committed to helping one another rise.
Her associates kidnapped Shelby in an attempt to have her colleagues, Alex and Ryan, work for them in order to obtain a mysterious object called the Conscience Code.