List of San Francisco 49ers first-round draft picks

[6] Since 2014 they have played their home games at Levi's Stadium in Santa Clara, California, located southeast of San Francisco.

[13] The draft order is determined based on the previous season's standings; the teams with the worst win–loss records receive the earliest picks.

Teams that qualified for the NFL playoffs select after non-qualifiers, and their order depends on how far they advanced, using their regular season record as a tie-breaker.

The team's first-round pick in their inaugural NFL draft was Leo Nomellini, a defensive tackle from the University of Minnesota; he was the 11th overall selection.

Nine of the team's first-round picks—Lance Alworth, Jimmy Johnson, Ronnie Lott, Hugh McElhenny, Leo Nomellini, Jerry Rice, Y.

Jerry Rice in a blue Nike shirt making the hang loose hand gesture.
The 49ers moved up in the first round of the 1985 NFL draft to pick future hall of fame wide receiver Jerry Rice with the 16th overall pick. [ 1 ] While playing for the 49ers, Rice was a 10-time first-team All-Pro , two-time NFL Offensive Player of the Year (1987 and 1993), and broke numerous NFL receiving records. [ 2 ] [ 3 ]
Ronnie Lott in a USC Trojans shirt.
Hall of Fame defensive back Ronnie Lott was drafted by the 49ers with the 8th overall pick in the 1981 NFL draft . [ 22 ] He spent 10 seasons with the team, during which time he was a seven-time All-Pro and nine-time Pro Bowler . [ 23 ] Lott was unanimously selected for the NFL 100th Anniversary All-Time Team . [ 24 ]
Alex Smith in a San Francisco 49ers uniform behind two linemen, about to take a snap.
Quarterback Alex Smith was selected first overall by the 49ers in the 2005 NFL draft . [ 25 ]
Nick Bosa in a 49ers jersey (with no helmet) smiling.
Defensive end Nick Bosa was drafted second overall by the 49ers in the 2019 NFL draft . Bosa was named the 2019 Defensive Rookie of the Year , 2022 Defensive Player of the Year , and has made 4 Pro Bowls . [ 26 ]