The following is a list of soundtracks from the animated television series The Powerpuff Girls, created by Craig McCracken, which ran on Cartoon Network from November 18, 1998, to March 25, 2005.

[7] The songs are connected by spoken interludes (recorded by the show's voice cast) to form a loose storyline in which the girls mobilize to stop Mojo Jojo from destroying Townsville.

[9] The New York Times journalist Ann Powers praised the pop album's original songs, saying, "The precocious sound these bands cultivate has never had a more appropriate niche.

"[2] Meanwhile, David Wild of Rolling Stone gave it 3 out of 5 stars, saying that "it's the indie-ish mix of acts that makes Heroes and Villains such a tuneful, trippy blast," highlighting The Apples in Stereo's "Signal in the Sky (Let's Go)" as a "propulsive, bubblegum-delicious" song that "nearly steal[s] the show.

"[17] Jon Caramanica wrote for Rolling Stone that "this series of femme-fronted acts articulate girl-power ideas so shallow they make the Spice Girls sound like feminist ideologues.