Highways in Nebraska are the segments of the national United States Numbered Highway System that are owned and maintained by the U.S. State of Nebraska totaling 3,553 miles (5,718 km).

On a national level, the standards and numbering for the system are handled by the American Association of State Highway and Transportation Officials (AASHTO), while the Nebraska Department of Transportation is responsible for their maintenance.

Route numbers are not reused between the various highway systems within the state.

NDOT is the agency responsible for the daily maintenance and operations of the State Highway System which includes the U.S.

The numbering for these highways is coordinated through AASHTO, an organization coordinating various state departments of transportation within the United States.