Amtrak has operated most intercity passenger rail transportation in the United States since May 1, 1971.
This list contains serious incidents – those with deaths or more than 20 injuries of passengers or railroad personnel – that have involved Amtrak trains.
(It does not include most grade crossing accidents and trespasser strikes that did not cause significant injury aboard the trains.)
The most number of fatalities in a single incident was 47 in the Big Bayou Canot crash in 1993, when the Sunset Limited fell off a bridge that had been struck by a barge eight minutes earlier.
Five other incidents have caused ten or more deaths: a 1987 collision with freight locomotives in Maryland, a 1971 derailment in Illinois, a 1996 collision with a commuter train in Maryland, a 1999 grade crossing accident in Illinois, and a 1977 grade crossing accident in Florida.