Both Residente and his step-brother Eduardo Cabra "Visitante" hold the record of the most Latin Grammy Award wins with 24 each.

The group's fifth and last album Multi Viral (2014) garnered Latin Grammy Awards for Best Urban Music Album, Best Alternative Song (for "El Aguante"), and Best Short Form Music Video (for "Ojos Color Sol"), and received nominations for Album of the Year, Record of the Year (for "Respira el Momento"), Song of the Year (for "Ojos Color Sol"), Best Urban Performance and Best Urban Song (for "Adentro"), and Best Short Form Music Video (for "Adentro" and "Así de Grandes Son Las ldeas").

His social commitment, lyrics, and contribution to popular culture garnered Residente recognitions by Amnesty International, the Ateneo Puertorriqueño, the National University of La Plata, the Nobel Peace Laureates, and the Broadcast Music, Inc. (BMI).

[5] Residente has received a special award for "his social commitment and identification with young people in Latin America.

[7][8] Calle 13 received the Ramón Emeterio Betances Medal in 2011 for "having fought for the permanence of the Puerto Rican identity and the freedom of the island.

He ties the record for the most Latin Grammy Award wins with his step-brother Eduardo Cabra "Visitante".

The Rodolfo Walsh Award is presented annually by the School of Journalism and Social Communication at the National University of La Plata in Buenos Aires Province, Argentina since 1997.

[48] Calle 13 has received the Rodolfo Walsh Award in 2012 for their "contribution to communication and popular culture.

[55] Residente has received the Nobel Peace Summit Award in 2015 for "his song lyrics and his support for social causes."