[6] Lithium perchlorate is used as an oxidizer in some experimental solid rocket propellants, and to produce red colored flame in pyrotechnic compositions.

[8] Lithium perchlorate is also used as a co-catalyst in the coupling of α,β-unsaturated carbonyls with aldehydes, also known as the Baylis–Hillman reaction.

[9] Solid lithium perchlorate is found to be a mild and efficient Lewis acid for promoting cyanosilylation of carbonyl compounds under neutral conditions.

[11] Concentrated solutions of lithium perchlorate (4.5 mol/L) are used as a chaotropic agent to denature proteins.

[12] Perchlorates often give explosive mixtures with organic compounds, finely divided metals, sulfur, and other reducing agents.