[4] Since performing as a solo artist, she has released four albums: Hands (2009), Nocturnes (2013), Working Girl (2015) and Tomorrow's Yesterdays (2022), and a number of associated EPs and remixes.

Hands reached number five on the UK Albums Chart and the singles "New in Town"[5] and "Remedy"[6] became top twenty hits.

[7] From the age of five, Hesketh played the piano and began lessons at six with Ruth Birchall,[8] eventually winning a music scholarship.

During this time she was taught how to play the flute, was a member of the school choir and travelled regularly to Manchester to take lessons on her harp.

[8] Hesketh attended the private Rossall School in Fleetwood,[9] and then the state Blackpool Sixth Form College;[10] it was around this time that she entered the ITV talent competition search Pop Idol aged sixteen.

[14] While studying at the University of Leeds, Hesketh answered an online advertisement posted by Lucy Catherwood and Marie France looking for a lead singer to start a band.

Working with Ford in his London attic studio, the band issued a limited release of their debut single "The Treatment" in April 2006 on the record label High Voltage.

With the success of several sell out gigs and an appearance at the Leeds Festival, the band moved to Los Angeles to begin recording their debut album with Greg Kurstin.

Choosing a new musical direction, Hesketh left Dead Disco; they officially revealed their disbandment on their Myspace blog in December 2008.

"[8] In a later interview Hesketh noted that the bands' label was pressuring the group to have a certain style and that her bandmates lost confidence in her because she wanted to write "cheesy" songs.

She returned to her parents' house to begin writing her own songs and posting covers on social networking sites such as YouTube and Myspace.

After appearing on several shows including Later... with Jools Holland and Last Call with Carson Daly, Hesketh entered production on her debut album Hands.

With increasing media attention regarding her then-yet-to-be-released debut album, Hesketh topped the BBC Sound of 2009 poll and received a Critics' Choice nomination at the 2009 BRIT Awards.

It includes "Stuck on Repeat", "New in Town", "Magical", "Love Kills" (a cover of Freddie Mercury's 1984 song) and "Not Now" (which is only available on the US edition).

"[29] ClashMusic.com reviewer Joe Zadeh disagreed, writing that the album "falls victim to attempts to reach beyond more boundaries than necessary, and thus ironically loses the concentration of the more earnest listener.

"[30] David Renshaw of Gigwise.com described Hands as "a big pop album" that "rival[s] Lady Gaga, Girls Aloud or Lily Allen.

"[31] Ben Thompson of The Guardian wrote that the album's production was "diverse" and called the song "Symmetry", a duet with Philip Oakey, a "joyous cross-generational head-to-head.

[40] With the release of her debut, she was linked to a recent wave of breakthrough female artists in their 20s playing 1980s-influenced music, including Lady Gaga, Ladyhawke, Florence and the Machine and Elly Jackson of La Roux.

[43] In October 2011, she released a mixtape called Shake Until Your Heart Breaks and announced that she would embark on an international DJ tour to promote her new material.

[52][53] Little Boots toured internationally in late 2012, including performances at San Francisco's Folsom Street Fair and Ibiza's Space.

In an interview with This Is Fake DIY, Little Boots said of the album: "I feel a lot more at peace about where I'm at creatively as an artist now than a year or so ago [...] I think everyone is always nervous releasing anything they've created into the world, but I've realised what I want to do and how I can achieve it, rather than trying to please other people."

"[63] In a November 2019 interview with The Guardian, Spice Girl Melanie C revealed she has been working with Little Boots on Chisholm's upcoming eighth studio album.

After joining ABBA Voyage in 2021, Little Boots announced that she would be releasing her fourth studio album, and unveiled its lead single "Silver Ballons".

[66] As a musician, Little Boots sings and plays the piano, keyboards, synthesizer, Stylophone and a Japanese electronic instrument called the Tenori-on.

[77] Little Boots performed "Remedy" and a cover version of JLS' "Beat Again" as part of the Live Lounge segment of BBC Radio 1's The Jo Whiley Show on 19 August 2009.

[85] The following month, Little Boots performed a set in the Gobi Tent at the Coachella Valley Music and Arts Festival in Indio, California.

[89] From October to November, she embarked on an international through Europe and South America performing in Madrid, Barcelona, Poland, Brazil and Chile.

[90] On 21 December, she uploaded a short feature on her official YouTube page, which showed behind the scenes footage of her touring in Brazil, Chile and Argentina.

[91] Little Boots announced in September 2021 that she has been chosen as one of ten musicians who will perform as a backup band for the ABBA concert tour using "ABBAtars", or digital avatars of the group.

[96] "Meddle" was featured in the ninth episode of the third series of the British teen drama Skins, titled "Katie and Emily" and broadcast 19 March 2009.