[3] It operates and franchises pizza restaurants in the United States and internationally in Asia, Europe, the Middle East, Canada, Latin America, and the Caribbean.

The first location was in a strip mall in Garden City, Michigan, a suburb of Detroit, and named "Little Caesar's Pizza Treat".

The original store closed in October 2018, relocating down the street to a new building in nearby Westland.

For a time, in addition to pizza, the menu included hot dogs, chicken, sub sandwiches, shrimp, and fish.

The concept was successful enough to become a permanent fixture of the chain, and Little Caesars' business model has shifted to focus more on carryout.

[9] On December 10, 2014, Little Caesars announced plans for a new eight-story, 205,000-square-foot Global Resource Center to be built at Woodward Avenue and Columbia Street in downtown Detroit.

Intended to double the size of Little Caesars World Headquarters Campus, the new building's location was chosen near the Fox Office Center building, which houses both the Fox Theatre, and 186,000 square feet of office space for Little Caesars, and other Ilitch-affiliated ventures.

An overhead pedestrian bridge over Columbia Street was planned to connect the Fox with the new Little Caesars Global Resource Center and workspace for an additional 600 jobs to be brought to Detroit over time.

[10][11] On January 31, 2016, it was announced that the proposed new Little Caesars Pizza Global Resource Center had grown by one floor to be a nine-story building at Woodward and Columbia Street.

[12] The building was scheduled to be completed in 2018, but in October of that year, was pushed back due to construction delays.

[20] As of 2022, the company is present in Canada (some Canadian cities had locations since 1969), Honduras, Nicaragua, Saudi Arabia, Costa Rica, Dominican Republic, Mexico (since 2006), Colombia, Panama, Peru, Turkey, Guatemala, Barbados, Bahamas, El Salvador, Jamaica, Bahrain, Trinidad and Tobago, Chile, Spain, and Singapore.

[24][25] In 2019, Little Caesars restaurants in Australia closed their doors and went into administration, having entered the Australian market in 2014.

[26] Little Caesars entered the Indian market on January 29, 2020, opening two stores in Ahmedabad, Gujarat.

"[37] In May 2019, Little Caesars began testing a pizza with meatless sausage made by Impossible Foods.