Situated in Centretown West, it is bounded by Albert Street to the north, Carling Avenue to the south, the O-Train Trillium Line to the west, and approximately Bronson Avenue to the east, while the neighbourhood's main commercial area is along Preston Street.

Little Italy is adjacent to Chinatown, whose business district centres on Somerset Street.

Following a fire at a small Murray Street chapel, the 1913 founding of St. Anthony of Padua Church at the corner of Booth Street and Gladstone Avenue cemented the immigrants' connections with the neighbourhood.

In 2018, Ottawa's tallest tower, the Claridge Icon, was built to the south end of the neighborhood at the intersection of Preston and Carling.

These projects are fueled by a recent service improvement announcement for the O-Train Trillium Line which will result in an eight-minute headway between trains at Carling Station as well as a new community design plan calling for high density near the transit station.