There are several Italian-American owned and operated businesses, including restaurants, law firms, and photographers located in Little Italy.

One of the central features of Little Italy is St. Anthony of Padua Roman Catholic Church, which also includes a grade school and the Padua Academy, located outside of Little Italy but nearby on Wilmington's west side.

St. Anthony's also hosts the Italian Festival, a week-long festival which takes place annually in June and celebrates Italian culture through food, music, a midway with rides and games, and games of chance generally found next to the church building.

[1] In 2010, a 78 minute documentary about the history of Little Italy and St. Anthony's Church titled Bells On The Hill was released.

The premiere screening sold out four days in advance at the local independent venue Theatre N. The film was written and directed by Gus Parodi[2] and Matt Swift.