The Little River originally flowed 27.0 miles (43.5 km)[1] from its headwaters in northern Oconee County, South Carolina near Salem into the Keowee River northeast of Seneca.

[3] In the early 1960s, the lower part of the Little River was flooded by the Lake Hartwell reservoir.

The upstream portion of the Little River remains free flowing.

[5] The Little River was in the heart of the Cherokee Lower Towns region.

This article related to a river in South Carolina is a stub.