The eastern peaks of the range were the traditional territory of the Wonnarua people.

[1] The Liverpool Range starts from the volcanic plateau known as the Barrington Tops and runs for about 100 kilometres (62 mi) westwards, forming the northern boundary of the Hunter Valley.

The Liverpool Range has a reputation as a breeding ground for severe summer thunderstorms.

The higher parts of the Liverpool Range reach approximately 1,300 metres (4,300 ft) above sea level, and the range formed a significant barrier to the expansion of settlement in the early period of British settlement in New South Wales.

The Main Northern railway line from Sydney to the Queensland border crosses under this pass via the Ardglen Tunnel.