[2] She designed greeting cards, gift books, and other paper goods for publishers L. Prang and Company—where she was a staff illustrator—and Lee and Shepard.

According to the book Art Work: Women Artists and Democracy in Mid-Nineteenth-Century New York, she "became a trendsetter for the publishing industry" due to her use of the technique.

[2] Along with several other Cooper Union students from the 1870s, Humphrey became one of the first women to "achieve recognition" as an illustrator in the United States.

While working for the company, her art was published as chromolithograph prints in gift books and greeting cards.

[17] In the 1880s, Prang also published an American literature series of high-end cards based on designs by Humphrey.

[18] Humphrey also illustrated for the publisher Lee and Shepard, creating works for their series of holiday poems[14] as well as their books.

[27][26] After her death that year, L. Prang & Co. announced that the last of her works made for the company would be published during the winter holidays.

[28] Prang & Co. also created and published a memorial book of her work, titled Child Life: A Souvenir of Lizbeth B.

[2][29] The book contained colored prints of her illustrations, as well as a portrait drawing of Humphrey, sketched by Mary J.