Luo Shu-lei was born in Datong District, Taipei, and grew up in Dadaocheng; her family was relatively wealthy because her father was engaged in the dyeing industry in Wanhua.

Later, she worked as the financial director and deputy general manager of a foreign company that imported American beef until she obtained the qualification as an accountant and established her own firm.

In November 2007, Luo Shu-lei succeeded Christina Liu, who had resigned her position as first-ranked legislator in the Non-Partisan Solidarity Union party list.

On the eve of the 2008 Taiwanese presidential election on March 12, 2008, four Kuomintang legislators, Luo Shu-lei, Fai Hrong-tai, Lo Ming-tsai and Chen Jie broke into the gated offices of Democratic Progressive Party candidates Frank Hsieh and Su Tseng-chang in the campaign headquarters of the Reform Hall.

[5] On September 10, 2014, Luo Shu-lei accused Taipei mayor candidate Ko Wen-je of money laundering and instigating and assisting others to evade taxes.

[7] During the 2022 Taiwanese local elections, Chiang Wan-an resigned as a legislator in order to run for mayor of Taipei City.

[8] After the election, she expressed her willingness to represent the Kuomintang in the by-election for the legislative vacancy in Taipei City's Third District, although she admitted in an interview with Taiwan Awakening that the chances were slim.

Luo Shu-lei and Huang Chao-shun were accused by his girlfriend Guo Xinzheng in the documentary short series "Who fell to death of Li Xin" hosted by Sheng Zhuru framed by them.

[10] In July 2021, after Huang Chao-shun and Luo Shu-lei accused Guo Xinzheng and Sheng Zhuru of not prosecuting for damaging their reputation, they filed for reconsideration but were rejected by the Taiwan High Prosecutors Office, and the entire case was confirmed.

[11] In the aggravated defamation part of the lawsuit, Guo Xinzheng was sentenced to 4 months in prison and fined 8,000 yuan, and Sheng Zhuru was detained for 50 days.