A follow-up was released May 2007 called Loaded Bible 2: Blood of Christ and it takes place right after the first one.

Loaded Bible 3: Communion was released February 2008 and is the conclusion to the first part of the series.

[2] The story starts with two acts: the discovery of vampires and the fact that the Christian religion has become much more fanatic.

Then, a nuclear global war caused by the religion turns The Earth into an uninhabitable territory.

Halo-8 Entertainment has optioned the rights to make an "illustrated film" of Loaded Bible to be directed by Matt Pizzolo, who had previously done Godkiller.