Lobelville is a city in Perry County, Tennessee, United States that was established as a trading post on the Buffalo River in 1854.

The proximity of the Tennessee River made this an unprofitable venture, and it never took off as a major trading point.

It is bisected by State Route 13, a connector to Interstate 40 (via exit 143 approximately 10 miles (16 km) north in Humphreys County, Tennessee) and U.S. Route 412 approximately 13 miles (21 km) south in Linden.

As of the 2020 United States census, there were 919 people, 461 households, and 290 families residing in the city.

Mousetail Landing State Park is situated south-west of Lobelville in Perry County along the Tennessee River.

Hunting, fishing, and camping (both at prepared sites and back-country) are widely available in the area.