The Moldovan participating broadcaster, TeleRadio-Moldova (TRM), organised the national final O melodie pentru Europa 2006 in order to select its entry for the contest.

The combination of votes from a jury panel and a public televote resulted in a tie that was not resolved, and therefore a second final took place on 15 March 2006 with five entries participating.

"Loca" performed by Arsenium and Natalia Gordienko featuring Connect-R emerged as the winner after gaining the most points following the combination of votes from the jury and public televote.

As one of the ten highest placed finishers in 2005, Moldova automatically qualified to compete in the final of the Eurovision Song Contest.

[2] O melodie pentru Europa 2006 was the national final format developed by TRM in order to select its entry for the Eurovision Song Contest 2006.

The thirteen qualifying entries competed in the final on 25 February 2006 where the winner was selected based on the combined votes from an expert jury and public televoting results.

[3] In the semi-final twenty-five acts competed and thirteen songs qualified to the final based on the votes of an expert jury.

[14] On 8 March 2006, TRM announced the organisation of a second final; the rules of the competition stated that the broadcaster possessed the right to nullify the results of the selection and choose an alternative entry if they felt the overall standard was not good enough for the Eurovision Song Contest.

[17] A jury selected four out of the eight received entries to advance to the second final which took place on 15 March 2006 at the TRM Studio in Chișinău, hosted by Rusalina Rusu and Bogdan Dascal.

[21] Both had also accused the broadcaster of setting up Arsenium's eventual victory with Stîrcea calling for him to withdraw "in order to keep its name", and had claimed several violations in regards to the jury and televoting procedure that connected to rigging.

[3] According to Eurovision rules, all nations with the exceptions of the host country, the "Big Four" (France, Germany, Spain and the United Kingdom) and the ten highest placed finishers in the 2005 contest are required to qualify from the semi-final in order to compete for the final; the top ten countries from the semi-final progress to the final.