They formerly competed in the South of Scotland Football League, which they joined in the 1992–93 season.

Manager Jim Thompson guided the club to their best-ever season in 2007–08, as they won the league title.

Winning the South of Scotland League gave Crichton passage to the 2008–09 Scottish Cup.

They initially played at New King Edward Park, ground sharing with Mid-Annandale.

In 2019 the club returned to Lochmaben after a new pavilion was constructed at Whitehills Park.