Upper Annandale Football Club are a football club from the town of Moffat in the Dumfries and Galloway area of Scotland.

The club was founded in 1966 and plays in the South of Scotland Football League.

They originally competed in the Dumfries & District Amateur Football League, but switched to the senior leagues in time for the 2014–15 season.

Home matches are played at Moffat Academy which accommodates approximately 1,000 spectators.

Uppers won the Dumfries & District AFL Division One title a total of five times, including four successive title between 2007 and 2010.