Lockjaw, an oversized dog and pet of the Inhuman Royal Family, finds the Mind Gem, which increases the animal's intelligence.

The pet encounters and recruits a number of other animal companions to heroes, including the cat Hairball, the diminutive dragon Lockheed, the falcon Redwing, the frog Throg and the puppy Ms.

Courtesy of Lockjaw's ability to teleport, the group visit the prehistoric Savage Land and acquire the Time Gem and the aid of the sabretooth tiger Zabu, and the Tyrannosaurus rex Devil Dinosaur.

The Titan Thanos, a previous owner of all six Gems when united as the Infinity Gauntlet, intervenes and kills Ms.

Retrieving the final Gem, the group decides to separate, but not before Throg advises that they now share a psychic link and will reunite if needed.