[21][22] The U.S.Avengers team consists of Robert Maverick / Red Hulk, Doreen Allene Green / Squirrel Girl, Samuel Zachary Guthrie / Cannonball, Aikku Jokinen / Enigma, Toni Ho / Iron Patriot, and the time-displaced Danielle Cage / Captain America who comes from an alternate future.

Their first mission puts them against the Secret Empire, who were planning to destroy the United States inside their floating volcanic island base.

They are later approached by a future version of Danielle Cage as Captain America, who tells them that her nemesis, the Golden Skull, came to their timeline to steal all the wealth.

In Miami, Florida, the team crash a charity gala only to discover that the wealthy CEO's were kidnapped and replaced by robots.

[26] During the "Opening Salvo" part of the Secret Empire storyline, Red Hulk stumbles upon the underground lair of Gorilla-Man and his army of Gorilla-Men.

Meanwhile, Steve Rogers has a meeting with Roberto da Costa and scolds him for his recent actions and Cannonball decides to quit the team so he could live with his wife Smasher and their son.

[27] Cannonball returns to Earth only to discover the Alpha Flight Space Program, the Guardians of the Galaxy, and the Ultimates' battle against the Chitauri.

Meanwhile, the team arrives in Washington D.C. to confront Hydra when Red Hulk begins to attack them due to nanites that were injected in him, which starts to control him.

While adjusting to prison life, Toni manages to heal Roberto just in time, when Hydra soldiers show up at their cell.

Meanwhile, Cannonball is sold at an auction to a human named Howard Mason and Squirrel Girl and Enigma help the Champions of Europe in raiding a Hydra base.

agents to be the organization's new leader and Squirrel Girl and Enigma are seen fighting the Plunderer and Blue Streak who were attempting to rob from the Project P.E.G.A.S.U.S.

[39][40] Jesse Schedeen of IGN gave U.S.Avengers #1 a grade of 8.2 out of 10, writing, "U.S.Avengers #1 doesn't break a lot of new ground when it comes to establishing a superhero team.