The Loddon Mallee is an economic rural region[1] located in the north-western part of Victoria, Australia.

[2] Occupying more than a quarter of the state, it stretches from Greater Melbourne to the northernmost point of Victoria, sharing a border with South Australia and New South Wales, and has one of the most consistently warm climates in Victoria.

Comprising an area in excess of 58,000 square kilometres (22,000 sq mi) this is the largest region in Victoria hosting a population of over 348,000 people.

The region comprises two distinct and inter-connected sub-regions or districts: Loddon Campaspe and Mallee.

[7] For the purposes of Victorian elections for the Legislative Assembly, the Loddon Mallee region is contained within all or part of the electoral districts of Bendigo East, Bendigo West, Euroa, Macedon, Mildura, Murray Plains and Ripon.