The hospital which opened in 1888 and closed in 1994 initially treated Smallpox but soon broadened its treatment to other infectious diseases and in its latter years expanded to provide more general nursing, notably spinal injuries and chest medicine.

[2] The hospital was deliberately sited in an area of high altitude, 950 feet (290 metres) above sea level, as it was believed this would provide the necessary fresh air for patients.

Further expansion to the hospital completed in 1905 saw the addition of the six South wards, the main lodge, waiting room and the square tower which is a conspicuous landmark in the surrounding area.

[1] The 1918 flu pandemic and the ensuing vastly increased number of admissions, severely overstretched the hospital's capacity and it was only the assistance of voluntary nurses which allowed the regular staff to cope.

Despite several attempts to restart the engine, the pilot, Roy G. Evans bailed out over the Derbyshire village of Hathersage leaving the aircraft to carry on in flight and hit Lodge Moor Hospital.

[1] The main hospital building including the tower has now been integrated into private residential accommodation built by the developers David Wilson Homes.