[2] Lohuecosuchus is a member of the clade Allodaposuchidae, a group of eusuchians that lived in southern Europe during the Late Cretaceous.

The type species, Lohuecosuchus megadontos, was recovered from the Lo Hueco fossil site of the Villalba de la Sierra Formation in the municipality of Fuentes, Cuenca Province at Castilla-La Mancha of central Spain.

[3] The second species, Lohuecosuchus mechinorum, was found at the Fox-Amphoux fossil site of the Grès à Reptiles Formation in the Department of Var in southeastern France, and was named after the discoverers of the holotype, Patrick and Annie Mechin.

[3] Lohuecosuchus was both synchronic and sympatric (lived at the same time and place) with another allodaposuchid species, Agaresuchus fontisensis.

[4] Lohuecosuchus is also closely related to Allodaposuchus, another genus from southern Europe that includes several species.